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Editorial



Dear all,

Welcome to our last newsletter of the year! 2016 has been very exciting and rewarding for COPE and I would like to use the occasion of this last 2016 newsletter edition to look back on our main achievements.

In February, COPE was represented at the British Transplant Society congress in Glasgow with a project booth as well as an e-poster allowing us to broaden our network and further increase visibility for our work. In March, the WP2 team completed patient recruitment in the liver trial leading to our most important milestone of the year, but WP2 has now also reached the 6-months follow-up period for its last patient in September and the team is busy with in-depth data analysis as we speak. The COPE Consortium then got together for the 4th Annual Meeting held in April and - as always - we have greatly appreciated our partners' and collaborators' valuable input culminating in a wonderful joint dinner at the Balliol College.

During the summer months, our liver trial presented its very exciting and important preliminary results of normothermic machine perfusion versus static cold storage in liver preservation at the American Transplant Congress in Boston (USA), The Transplant Society congress in Hong Kong (PRC) and the DCD conference in Barcelona (ES). All presentations were very well received and raised great interest in the transplant community. The summer months also brought along the official project extension approval confirming the new end date of June 2018 and COPE submitted its 2nd interim scientific and financial report to the EU Commission.

We furthermore saw our partnership grow and expand with Cardiff & Vale University (UK), the Royal Free Hospital (UK), Hammersmith Hospital (UK), UCL (BE) and Semmelweis University (HU) joining our POMP trial and we are delighted about these new collaborations. Our COPE partner Poitiers started the planned experimental work based on the revised protocols - we are excited to read up on the first findings. Finally, the end of 2016 sees us at 80% of recruitment target in the COMPARE trial and 45% of recruitment target in the POMP trial and we look forward to finishing inclusions in 2017. 

These are very impressive achievements for one year and it was only possible thanks to all our partners', collaborators' and supporters' hard work and dedication. On behalf of the entire COPE Consortium, I would like to thank you for your ongoing commitment, your good ideas and your bountiful energy to bring our joint work forward. We truly appreciate your time and effort and wish you a wonderful festive season with your family and loved ones. 

With best wishes,

WP2 - Normothermic machine perfusion trial


  • The COPE WP2 liver trial has been featured in ‘What Clinical Changes can we Expect in the Next 5 Years’ review article in the journal Transplantation. Get in touch with the COPE Project Office if you'd like to receive a digital copy of the review article. 
  •  The DCD results were presented at the 7th International Meeting on Transplantation from DCD.
  •  The 6 month data lock for COPE WP2 occurred at 23:59 on 24 October 2016. The data is currently being analysed.
  •  The results have been submitted for presentation at the British Transplant Society annual congress in 2017. 

WP3 - POMP Trial: oxygenated HMP re-conditioning of ECD kidneys


  • The POMP trial has randomised 107 ECD kidneys as of 28 November 2016. 
  • All teams are working hard to include the additional sites in Berlin and in Budapest

WP4 - COMPARE Trial: oxygenated HMP of DCD kidneys


  • As of 29 November 2016, WP4 has randomised 149 donor pairs, of which 79 pairs have been included in the trial. With a trial target of 99 pairs, this constitutes 80% of the overall trial recruitment.
  • Some randomised pairs are lost, particularly if one kidney is declined at the recipient centre or if a kidney is allocated to a country outside of the COMPARE zone. 
  • With the current recruitment rate, we hope to recruit our last kidney pair in March 2017.
COPE Transplant Technicians on the Continent during their most recent driving training with the partner Med-Assist for our COMPARE trial!

WP5 & WP6 - Experimental work programmes


  • Our partner Poitiers has now started its experimental work based on the new protocols devised within WP5 and WP6. The entire partnership is looking forward to first results once the first set of experiments has been completed. 

WP7 - Biobank


  • The COPE biobank received a further shipment of continental samples in October 2016. 
  • WP7 furthermore equipped our new POMP site in Budapest with all logistical aspects required for sample collection including collection kits, freezer storage boxes and transport materials for the shipments back to Oxford. 
  • WP7 is also working with the received research proposals for the liver trial to determine sample needs in more detail, particularly in light of the new collaborations formed around bile duct research and ischemia reperfusion injury (IRI) and histology research.
  • For the liver trial, a small set of formalin fixed paraffin embedded tissue samples has been cut and sections have been sent to our COPE Pathologists to devise a scoring system for steatosis and IRI that will over time be applied to all liver trial samples. This information will create an important library that other research groups can work with reducing the need for sample shipments and ensuring a highly efficient use of our existing resource.  
  • If any partner site has questions on sample collection, sample handling, sample tracking in the database or sample shipment, please get in touch with our Biobank Manager, Bhumika Patel. 

WP8 - Trial design and methodology



no current updates to report

WP9 - Communication and dissemination


         

WP10 - Management


  • The COPE partnership has now fully implemented the changes approved in the 2nd COPE amendment towards the EU Commission - particularly the project extension until June 2018. for that purpose, the partnership held separate conference calls to discuss the new timelines, the budget usage and the upcoming steps. 
  • In the New Year, the COPE Project Office will turn its attention to the next COPE Annual Meeting scheduled for early April 2017. If you have any suggestions or content wishes, please don't hesitate to share them with us.  
  • We will soon send the internal reporting templates for the second semester 2016 to our COPE partners to be filled by end of January 2017. If you have any questions about the COPE internal reporting, please get in touch!
  • We will soon schedule the next round of COPE Management Board calsl - just watch out for the doodle poll coming your way. 
Copyright © 2016  COPE  All rights reserved.
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This project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement 305934.






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University of Oxford · Churchill Hospital · Oxford Transplant Centre · Oxford, Oxfordshire OX3 7LE · United Kingdom

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