HOT Talks Announced: Register for the Nanion User Meeting!
Register today for our annual user meeting! 19th - 20th October 2022
We are delighted to announce that we will hold our Annual User Meeting 2022 as a live event on 19th - 20th October 2022. Join us for 2 days of outstanding talks, product demos, SyncroPatch 384 workshop, posters, networking and much more!
It's coming home: The SyncroPatch 384 is installed in Göttingen, the birthplace of patch clamp!
We are pleased to announce that the SyncroPatch 384 has been installed at the MBExC Cluster of Excellence at the University Medical Centre Göttingen (UMG) to advance investigation into the electrical activity of isolated cardiomyocytes and neurons.
Nanion celebrated 20 years of innovat]i[on with our fabulous colleagues (past and present), collaborators, customers, family and friends.
TOPIC TMEM16A and its role in cancer
TMEM16A: a novel drug target for NSCLC
TMEM16A, also known as Anoctamin 1 (ANO1) is a calcium-activated chloride channel which has a broad functional spectrum in processes including trans-epithelial ion transport, olfaction, photo-transduction, smooth muscle contraction, nociception, cell proliferation and control of neuronal excitability. It is is overexpressed in non-small cell lung cancer (NSCLC), a major cause of cancer-related mortality and is a novel potential drug target for NSCLC. In a recent paper, researchers found that the anticancer mechanism of the compound verteporfin is caused via the down-regulation of ANO1.
TMEM16A can be measured using automated patch clamp. Read more about activation of TMEM16A by internal perfusion of Ca2+ in this Application Note.