hDMT newsletter July 2016

In this hDMT Newsletter
Upcoming events
Past events
Focus on junior hDMT researchers
Grants and awards
Recent publications
hDMT activities
hDMT in the news
Popular science
More about hDMT
Dear reader,

According to a list published on June 23 2016 by the World Economic Forum, Organs-on-chips are amongst the top 10 emerging technologies of 2016. To compile this list the World Economic Forum’s Meta-Council on Emerging Technologies, a panel of global experts, drew on the collective expertise of the Forum’s communities to identify the most important recent technological trends. By doing so the Meta-Council aims to raise awareness of their potential and contribute to closing gaps in investment, regulation and public understanding.

On the same day, during the European Conference Industrial Technologies 2016 in Amsterdam, the Policy Recommendations, (Amsterdam Declaration Creating a Smart Europe) were presented. This Declaration focuses on topics in the areas of nanotechnology, digitization and biotechnology and aims to speed up the arrival of the fourth European industrial revolution. Collaboration, openness, trust and acceleration were the keywords during this conference to achieve this goal.

The importance of Organs-on-chips as a revolutionary platform for biomedicine, the healthcare sector and industry is gaining ground in the agendas of the Dutch (National Research Agenda, in Dutch only) and European (MASRIA) research policy makers. It is the intention of hDMT to contribute to further development and implementation of this technology as part of a collaborative ecosystem with expert organizations worldwide.
We hope you will enjoy this second hDMT newsletter,

Christine Mummery, Janny van den Eijnden-van Raaij and Mieke Schutte
Executive board hDMT 
Upcoming events
Past events

hDMT starts Brain-on-chip program

The hDMT Brain-on-chip group has officially kicked-off with a meeting of partners at ErasmusMC in Rotterdam (11 July, 2016). Coordinator of the brain-on-chip program is Steven Kushner (ErasmusMC). More

Organ-on-chip technology and hDMT at Industrial Technologies 2016

At the invitation of the Dutch Ministry of Economic Affairs, hDMT was present at Industrial Technologies in Amsterdam - and showed its chips. More

Keynote lecture on Organ-on-chips at ISOCS-MINAB-ICT-MNBS 

Janny van den Eijnden-van Raaij gave a keynote lecture on organ-on-chip technology and hDMT at the joint event of the International Society on Olfaction and Chemical Sensing (ISOCS) and the European Commission (Micro Bio Nano Convergence Systems, MNBS) on 25-29 June, 2016 (Otranto, Italy). More

Anja van de Stolpe was invited speaker at Nanocity 2016

If you missed her talk about In vitro human organ and disease culture models
towards in vitro '(pre-)clinical trials-on-chips', you can listen to it here

Focus on junior hDMT researchers

Microfabrication and microfluidics for 3D brain-on-chip (UTwente & TU/e)

PhD thesis of Bart Schurink on Micro-fabrication and microfluidics for 3D brain on a chip, (23 June 2016, University of Twente, Meso Scale Chemical Systems group, MESA+ Institute for Nanotechnology).
Promotor: Han Gardeniers (University of Twente); copromotor: Regina Luttge (TU/e).
Grants and awards

hDMT starts Organs-on-chips technology platform

Eindhoven Technical University, University of Twente, and Delft Technical University are launching the first hDMT project 'Organs-on-chips technology platform'. The project will run until the end of 2016. It consists of exploratory workshops, joint pilot projects, a digital forum for information exchange and access to a relevant conference in technology development. The project is financed by NanonextNL. More

ERC Proof of concept subsidy for University of Twente

Mathieu Odijk, Loes Segerink and Albert van den Berg of the BIOS Lab-on-a-chip group (MESA+/MIRA) have received an ERC proof of concept grant. They will use it to adapt their technique for monitoring the quality of cells on chips to a user-friendly device, the BioRead. This device will be able to monitor several organ-on-chip systems at once. More
Recent Publications
Measuring physiological responses of human pluripotent stem cell derived cardiomyocytes to drugs and disease Van Meer BJ, Tertoolen LG, Mummery CL. Stem Cells. 2016 Jun 2. doi: 10.1002/stem.2403

Stem cells: The cancer's gone, but did chemotherapy damage your heart? Bellin M, Mummery CL. Nat Rev Cardiol. 2016 May 26. doi: 10.1038/nrcardio.2016.88. 

SnapShot: Key Advances in hiPSC Disease Modeling Orlova V, Mummery C. Cell Stem Cell. 2016 Mar 3;18(3):422. doi: 10.1016/j.stem.2016.02.013.

Complex Tissue and Disease Modeling using hiPSCs Passier R, Orlova V, Mummery C. Cell Stem Cell. 2016 Mar 3;18(3):309-21. doi: 10.1016/j.stem.2016.02.011. Review.

A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors Den Hartogh SC, Wolstencroft K, Mummery CL, Passier R. Sci Rep. 2016 Jan 19;6:19386. doi: 10.1038/srep19386.

Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment Middelkamp HHT, van der Meer AD, Hummel JM, Stamatialis DF, Mummery CL, Passier R, IJzerman MJ Applied In Vitro Toxicology, Jun 2016, 2(2): 82-96.
hDMT activities

Cancer-on-chip technology and accessible cancer medicines

hDMT has submitted 'Cancer-on-Chip Technology: the Revolution in Cancer Care' as an innovative business model on a symposium on accessible cancer medicines, organised by the Dutch Cancer Society (KWF). hDMT's business model was selected as one of three pitches to be presented at the symposium. The presentation was held by Mieke Schutte. More

Organ-on-chip proposed for Horizon 2020 

hDMT has submitted consultation forms to the Netherlands delegations in the Horizon 2020 Programme Committees for LEIT-ICT and for Health. In this way organ-on-chip technology might be included as one of the new topics in the coming H2020 work programs. hDMT has already received support for this topic from other European countries, including Germany, Portugal and Switzerland. More 

Organ-on-chip now focus area in ECSEL's MASRIA

Human organ and Disease Model Technologies/Organ-on-chip is mentioned as focus area for 'Personalized Medicine' within the key application 'Smart Health' of the 2016 ECSEL Multi Annual Strategic Research and Innovation Agenda (MASRIA). MASRIA identifies and explores specific Electronic Components and Systems (ECS) technology solutions for smart applications relevant for societal challenges and industrial leadership in Europe. More 

Organs-on-chips and the Dutch National Research Agenda 

The Route workshop 'Regenerative Medicine' (30 March, 2016) has resulted in a formal advisory document ('uitkomsten routeworkshop', in Dutch only) for the NWA steering group, based on the workshop results. hDMT participated in this workshop and in the committee writing the advice. The advice will be analyzed by the steering group and used as input for the concept investment agenda for the Dutch government. More 

Cytostretch and 1 year InForMed

The Cytostretch Organ-on-Chip device developed by TUDelft is one of the demonstrators in the European project InForMed, which has been running since June 2015. Now, one year into the project, a clear path has been designed to turn Cytostretch into a high volume manufacturable product, that is validated and integrated into the Multichannel System's readout system. More
hDMT in the news

Organs-on-chips on primetime Dutch television

Ronald Dekker (Delft University of Technology) and Joost Gribnau (Erasmus MC) talked about organs-on-chips and hDMT on primetime Dutch Television (RTL, 16 June 2016, in Dutch).
Popular Science

All about Stem cells

Everything you always wanted to know about stem cells: science, reality and fiction. Cahier in Dutch, published by BioWetenschap en Maatschappij (ZonMW). Edited by Bernard Roelen, with contributions from Christine Mummery (Leiden University Medical Centrer) and Hans Clevers (Hubrecht Institute). Paper version: E 7,50 or PDF free download

Marileen Dogterom appointed as Medical Delta professor
and elected as KNAW member 

Professor of bionanoscience Marileen Dogterom (TU Delft) is apppointed as a dual professor at Leiden University Medical Center in the context of Medical Delta, a network of life sciences, health and technology organisations in Leiden, Delft en Rotterdam (The Netherlands). She was also elected as a member of the Royal Netherlands Academy of Arts and Sciences  (KNAW). Marileen Dogterom is a member of the consortium assembly of hDMT. More

Thomas Hankemeier appointed as Medical Delta professor

Analytical Bioscientist Prof. Thomas Hankemeier (Leiden University) is appponted as a dual professor at Erasmus MC in the context of Medical Delta, a network of life sciences, health and technology organisations in Leiden, Delft en Rotterdam (The Netherlands). Thomas Hankemeijer is a member of the consortium assembly of hDMT. More 
More about hDMT

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