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Winter 2020
IN THIS EDITION
CBTN Investigators Join the International Pediatric Neuro-Oncology Community for ISPNO 2020
 
Since its first meeting in Tokyo, Japan in 1986, the International Society for Pediatric Neuro-Oncology (ISPNO) has been considered one of the world’s most distinguished meetings of researchers and clinicians specializing in the field of pediatric neuro-oncology.

ISPNO provides a space for the sharing of research findings, presentations, and symposia covering nearly all angles of research and treatment for children and young adults with brain/CNS cancers, including diagnosis, clinical trials, novel treatment, basic and translational researches, neuroradiology, psychology, quality of life, nursing and patients’ care.


Children’s Brain Tumor Network (CBTN) investigators from nearly all of our 25 member sites will join this global community of experts in childhood brain cancer to engage in the sharing of research and new perspectives. In addition, CBTN will give several presentations and abstracts to share our research methodology and recent discoveries.
 





 
First Large-Scale, Multicenter Proteogenomic Analysis Offers New Insights Into Pediatric Brain Tumor Biology

Data reported can guide new therapeutic avenues for pediatric patients

A comprehensive “proteogenomic” analysis of the proteins, genes, and RNA transcription involved in pediatric brain tumors has yielded a more complete understanding of these tumors, which are the leading cause of cancer-related deaths in children. The results could help physicians more accurately identify different types of tumors and methods for treating them.

Researchers from the Children’s Brain Tumor Network (CBTN) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) collected and analyzed what’s known as genetic, genomic, and proteomic data from multiple types of brain tumors in children. The consortia consist of collaborators from the Icahn School of Medicine at Mount Sinai, National Cancer Institute, Fred Hutchinson Cancer Research Center, Children’s National Hospital, and Children’s Hospital of Philadelphia. The study, the first large-scale multicenter study focused on pediatric brain tumors, was available online in Cell on November 25.

 

 

 
Join us live at facebook.com/CBTNetwork for an hour-long panel discussion with CBTN and CPTAC experts to explore their landmark study, and hear how these insights could change the treatment landscape for countless children around the world.

While watching, you can submit Facebook comments and questions for our moderator to share with our panel of guests! If you have advance questions or comments, send them in to us at
communications@cbtn.org!

PANELISTS INCLUDE:
  • Amanda Paulovich, MD, PhD
    Professor, Clinical Research Division; Fred Hutchinson Cancer Research Center
     
  • Francesca Petralia, PhD
    Assistant Professor, Genetics and Genomic Sciences; Icahn School of Medicine, Mt. Sinai 
     
  • Adam Resnick, PhD
    Scientific Co-Chair; CBTN
    Director, Center for Data Driven Discovery in Biomedicine; Children's Hospital of Philadelphia

     
  • Miriam Barry
    Board Member; Children's Bran Tumor Foundation
    Patient Family Member
  • Henry Rodriguez, PhD, MS, MBA
    Director, Office of Cancer Clinical Proteomics Research; National Cancer Institute
     
  • Brian Rood, MD
    Executive Co-Chair; CBTN
    Director, Clinical Neuro-Oncology; Medical Director, Brain Tumor Institute; Children’s National Health System

     
  • Pei Wang, PhD
    Professor, Genetics and Genomic Sciences; Icahn School of Medicine, Mt. Sinai
NEW BIOSPECIMEN PROJECTS
(Approved Since October 2020)
See all CBTN Projects at cbtn.org/projects

CBTN Biospecimen Project 76
Oncogene-Induced Senescence in RTK-fused Infant High Grade Gliomas
Principal Investigator: David Kram, MD, MCR; Wake Forest Baptist Health - Brenner Children's Hospital

CBTN Biospecimen Project 77
Use of ependymoma cell lines to test for new therapeutic vulnerabilities
Principal Investigator: Marcel Kool, PhD; Hopp Children's Cancer Center, Heidelberg

CBTN Biospecimen Project 78
Biomarker Identification for Neurofibromatosis Type 2 Background
Principal Investigator: Andrew Mullen

CBTN Biospecimen Project 79
CAR T Cell Therapy for Neurofibromatosis 2 (NF2)
Principal Investigator: Christine Brown

CBTN Biospecimen Project 80
Characterizing the blood brain pediatric brain tumors 
Principal Investigator: Mark Souweidane, MD; Weill Cornell Medicine

CBTN Biospecimen Project 81
Genetic vulnerabilities in supratentorial and infratentorial pediatric high-grade gliomas
Principal Investigator: Massimo Squatrito, PhD; Centro Nacional de Investigaciones Oncologicas

CBTN Biospecimen Project 82
Investigating the tumorigenesis mechanisms and vulnerabilities of pediatric high-grade gliomas with H3G34R/V
Principal Investigator: Yang Shi, PhD; Children’s Hospital Boston, Harvard Medical School 

CBTN Biospecimen Project 83
MET alterations in DMGs
Principal Investigator: Payal Jain, PhD; Children's Hospital of Philadelphia
NEW DATA PROJECTS
(Approved Since October 2020)

See all CBTN Projects at cbtn.org/projects

CBTN Data Project 119
Using machine learning methods to identify patterns in the data that may lead to early identification of brain cancer
Principal Investigator: Matthew Emanuel

CBTN Data Project 120
Identification of novel therapeutic approaches for pHGGs
Principal Investigator: Massimo Squatrito, PhD; Centro Nacional de Investigaciones Oncologicas

CBTN Data Project 121
N/A
Principal Investigator: Kevin Judy, MD; Thomas Jefferson University Hospital

CBTN Data Project 122
Leveraging existing pediatric low-grade tumor specimens, clinical and imaging outcome data and artificial intelligence innovations to develop integrated biomarkers of response for children with low-grade glioma
Principal Investigator: Benjamin H. Kann, MD; Boston Children's Hospital

CBTN Data Project 123
Landscape of germline histone mutations in pediatric brain tumor patients
Principal Investigator: Javad Nazarian, PhD, MSc; Children’s National Hospital 

CBTN Data Project 124
N/A
Principal Investigator: Sabine Mueller, MD, PhD; UCSF Benioff Children's Hospital

CBTN Data Project 125
Characterizing the blood-brain-barrier in pediatric brain tumors
Principal Investigator: Mark Souweidane, MD; Weill Cornell Medicine

CBTN Data Project 126
Analyzing the relationship between the expression of specific genes and the prognosis in pediatric gliomas
Principal Investigator: Feng Wan
REQUESTING CBTN BIOSPECIMENS AND DATA

The CBTN accepts requests for CBTTC cell lines and data projects year-round, with resources available to researchers anywhere on earth.  And NOW,  proposals for scientific biospecimen projects from investigators will also be accepted any time of year!

For more information and instructions on submitting requests for CBTN biosamples, cell lines, and data, visit us online at: https://redcap.chop.edu/surveys/?s=A7M873HMN8
GIFT FROM A CHILD PROGRAM SEEKS FAMILIES TO SHARE #MEMORYMONDAY STORIES

As our followers on social media may have see, CBTN is celebrating a new campaign organized by our research partners, the Gift from a Child Program. Since the end of October, the Swifty Foundation-led initiative has shared weekly stories for its #MemoryMonday series on Facebook, encouraging families to recall memories of children who have passed too soon from cancer. They are providing this space as a forum to recall and relish the joys, adventures, and love that bind parents and families to their children.

Continuing over coming months, GFAC will share a new family memory each week and provide a prompt for others to share a similar memory. The campaign is eager to collect more stories, and we encourage you to reach out with your own, to ensure the memories of our children continue to inspire joy.

To share your story, contact them at
info@giftfromachild.org or on Facebook at facebook.com/GiftFromAChild.
RECENT PUBLICATIONS
(Published Since October 2020) 

See all CBTN Publications at cbtn.org/publications

Petralia F, Tignor N, Reva B, Koptyra M, Chowdhury S, Rykunov D, Krek A, Ma W, Zhu Y, Ji J, Calinawan A, Whiteaker JR, Colaprico A, Stathias V, Omelchenko T, Song X, Raman P, Guo Y, Brown MA, Ivey RG, Szpyt J, Guha Thakurta S, Gritsenko MA, Weitz KK, Lopez G, Kalayci S, Gümüş ZH, Yoo S, da Veiga Leprevost F, Chang H-Y, Krug K, Katsnelson L, Wang Y, Kennedy JJ, Voytovich UJ, Zhao L, Gaonkar KS, Ennis BM, Zhang B, Baubet V, Tauhid L, Lilly JV, Mason JL, Farrow B, Young N, Leary S, Moon J, Petyuk VA, Nazarian J, Adappa ND, Palmer JN, Lober RM, Rivero-Hinojosa S, Wang L-B, Wang JM, Broberg M, Chu RK, Moore RJ, Monroe ME, Zhao R, Smith RD, Zhu J, Robles AI, Mesri M, Boja E, Hiltke T, Rodriguez H, Zhang B, Schadt EE, Mani DR, Ding L, Iavarone A, Wiznerowicz M, Schürer S, Chen XS, Heath AP, Rokita JL, Nesvizhskii AI, Fenyö D, Rodland KD, Liu T, Gygi SP, Paulovich AG, Resnick AC, Storm PB, Rood BR, Wang P, Children’s Brain Tumor Network, Clinical Proteomic Tumor Analysis Consortium. Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer. Cell. 2020 Nov 20; Available from: http://dx.doi.org/10.1016/j.cell.2020.10.044 PMID: 33242424

Schieffer, K.M., Agarwal, V., LaHaye, S., Miller, K.E., Koboldt, D.C., Lichtenberg, T., Leraas, K., Brennan, P., Kelly, B.J., Crist, E., Rusin, J., Finlay, J.L., Osorio, D.S., Sribnick, E.A., Leonard, J.R., Feldman, A., Orr, B.A., Serrano, J., Vasudevaraja, V., Snuderl, M., White, P., Magrini, V., Wilson, R.K., Mardis, E.R., Boué, D.R., Cottrell, C.E.
YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. The American Journal of Surgical Pathology. 2020 Oct 16.
UPCOMING DATES
 
 
CBTN/CPTAC Panel Discussion
TOMORROW, December 17
2:00pm-3:00pm/ET (11am/PT)
Watch LIVE at:
facebook.com/CBTNetwork
Panel recording will be archived at facebook.com/CBTNetwork/videos

CBTN Data, Cell-Line, and Biospecimen Requests
Now Accepted Year-Round!
Submit a Request

CBTN User Support Office Hours
Next Session
TOMORROW, December 17
3:00pm-4:00pm/ET

January Session - TBD
email
research@cbttc.org for call-in details

CBTN Community Information Session
Next Session
January 2021
email
communications@cbttc.org or visit us at facebook.com/CBTNetwork for updates

CBTN Executive Board & Scientific Committee Quarterly Call
Thursday, January 28th 

beginning at 5:00pm/ET

CBTN Newsletter - Next Edition
March 2021
click to subscribe
STAY CONNECTED
 

 
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