Dear reader,
Here we present the first hDMT newsletter in 2017, full of new highlights in the field of organ-on-chip.
New partners
As of 1 January 2017, hDMT has two new partners. We are pleased to welcome
Welcome at the 2nd International Organ-on-Chip symposium
The École Polytechnique Fédérale de Lausanne (EPFL) and hDMT are happy to invite you for the second International Organ-on-Chip Symposium (IOOCS17). This symposium will be held at EPFL, Lausanne, Switzerland on 2-3 May, 2017. IOOCS17 brings together researchers from different fields to discuss recent developments in organ-on-chip technology and its applications. You will be inspired by international leaders in the field of organ-on-chip technology:
- Nancy Albritton, University of North Carolina, Chapel Hill, USA
- Anne Grapin Botton, University of Copenhagen, Copenhagen, Denmark
- Kevin Healy, University of California, Berkeley, USA
- Roger Kamm, MIT, Cambridge, USA
- Christine Mummery, Leiden University Medical Center, Leiden, The Netherlands
The symposium is a unique opportunity to meet these speakers, and interact with other international scientists in an interactive poster session and a ‘Meet-the-experts’ lunch. The annual series of IOOCS symposia is an initiative of hDMT. After a first successful meeting at University of Twente in The Netherlands in 2016 (IOOCS16), this year’s symposium will be hosted by the Institute of Bioengineering at EPFL.
The organizing committee:
Matthias Lutolf (chair, EPFL)
Albert van den Berg (hDMT)
Christina Mattsson (EPFL)
Christine Mummery (hDMT)
Dietrich Reinhard (EPFL)
Philippe Renaud (EPFL)
Janny van den Eijnden-van Raaij (hDMT)
More information about the symposium and a link to the registration process can be found on the hDMT website. We look forward to your participation and hope you will enjoy the symposium.
For all other hDMT news: please scroll down.
We hope you will enjoy this newsletter.
 Christine Mummery, Janny van den Eijnden-van Raaij and Mieke Schutte
Executive board hDMT
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International Organ-on-Chip Symposium 2017
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 Open for registration!
The 2nd International Organ-on-Chip Symposium 2017 (IOOCS17) will be hosted at the Institute of Bioengineering at EPFL, Lausanne, Switzerland on 2-3 May 2017.In this two-day symposium researchers from different fields are brought together to discuss how chip technology and (stem) cell biology can be combined to ... More
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 Blog: Coincidence or luck?
Visiting the hDMT technology platform workshop to 'mix-and-match' - A true story (by Yolande Ramos, LUMC). Almost a year ago, I first heard about hDMT. Immediately I got very enthusiastic: ‘this really is a fantastic initiative’, I thought. Organs-on-Chips had been around for a while already, but by facilitating the union bet... More
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- IPPP Day: Innovation through co-creation Utrecht, The Netherlands, 7 March 2017
- ICT.OPEN Utrecht, The Netherlands, 21 & 22 March 2017
- International Organ-on-Chip Symposium (IOOCS17) Lausanne, Switzerland, 2-3 May 2017
- Organ-On-A-Chip (a SELECTBIO conference) Munich, Germany, 10 - 11 May 2017. One of the speakers will be Marcel Karperien (UTwente)
- Microfactories for tissue engineering, or: Regeneration-on-a-chip Davos, Switzerland, 26 - 30 June 2017. Pamela Habibovic of the MERLN Institute (MUMC+) will chair the symposium
- 10th World Congress on Alternatives and Animal Use in the Life Sciences Seattle, Washington, USA, 20 - 24 August 2017
- Keystone Symposium: Organs- and Tissues-on-Chips Big Sky, Montana, USA, 8-12 April 2018 Christine Mummery is organizer and speaker (LUMC)
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 hDMT at Health-RI Conference
Connecting Researchers, Patients and Enabling Technologies Worldwide, personalized medicine is recognized as the next big dot on the horizon for health care. The Health-RI conference on December 1st 2016 has given an insight into current and future developments of health research infrastructure. Download presentations
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 Organ-on-Chip at International Micro Nano Conference 2016
13 & 14 December 2016 the International MicroNanoConference took place in the Beurs van Berlage in Amsterdam. We’re looking back at a great event with impressive keynotes and inspiring presentations (download them here). More
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 Non-animal approaches; the way forward
Christine Mummery held a presentation on stem cells at a conference organised by the European Union. The conference was intended as a dialogue with the scientific community and stakeholders, on how to exploit the advances in science towards phasing out animal testing. More
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 MNBS 2016 report
The report on the 10th Annual Concertation and Consultation Workshop on Micro-Nano-Bio-Systems (MNBS 2016) has been published. hDMT participated in the workshop. The report mentions organ-on-chip technology as one of the promising MNBS areas for new discoveries and applications(Download it here). More
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Focus on junior hDMT researchers
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 A journey towards an extrahepatic islets delivery device with a tissue engineering toolbox in hand (UTwente)
PhD Thesis of Giulia Marchioli on clinical islet transplantation in type I diabetes patients More
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 Microgel technology for improved beta cell transplantation (UTwente)
PhD thesis of Sieger Jacob Henke on strategies to encapsulate (beta) cells in micro hydrogels More
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 NWO grant for cancer-on-chip
A team led by hDMT researcher Roland Kanaar (Erasmus MC) received an NWO grant in the programme Building Blocks of Life. The team will visualize and quantitate the fundamental process of the DNA damage response, using a microfluidic cancer-on-chip approach. More
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 NWO grant for gut-on-chip
A team led by hDMT Researcher Hans Bouwmeester (Wageningen University & Research) has received am NWO grant in the programme Building Blocks of Life. The team will unravell the functional dynamics between the human gut microbiome and intestinal inflammatory responses More
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 Two hDMT projects granted by ZonMw
ZonMw granted two projects by hDMT researchers: Human stem cell-based high-throughput screening platform for cardiac disease (Robert Passier) and Diseased cardiomyocytes from human stem cells for drug-repurposing and safety pharmacology (Christine Mummery). More
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 European grant for hDMT researcher
Two projects were granted by ERA-CVD Joint International Call. Robert Passier (UTwente) and Christine Mummery (LUMC) and Milena Bellin (LUMC) are the hDMT researchers involved. More
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New organ-on-chip publications in hDMT
Gaio, N. et al (2016) Cytostretch, an Organ-on-Chip Platform (Micromachines)
Du, G. et al. (2016) Microfluidics for cell-based high throughput screening platforms – A review (Analytica Chimica Acta)
Ravetto, A. et al. (2016) A membrane-based microfluidic device for mechano-chemical cell manipulation (Biomedical Microdevices)
Van Spreeuwel, A.C.C. et al (2017): Mimicking cardiac fibrosis in a dish: fibroblast density rather than collagen density weakens cardiomyocyte function (Journal of Cardiovascular Translational Research, in press)
Van der Helm, M.W. et al (2016): Direct quantification of transendothelial electrical resistance in organs-on-chips (Biosensors and Bioelectronics)
Kamperman, T et al (2016): Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macrenvironments (Advanced healthcare materials)
Henke, S.J. et al: (2016): Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels (Macromolecular bioscience)
Van Meer, B.J. et al (2016) Small molecule absorption by PDMS in the context of drug response bioassays (Biochemical and Biophysical Research Communications)
Xie S et al. (2016): Displacement Talbot lithography nanopatterned microsieve array for directional neuronal network formation in brain-on-chip Brain-on-chip (Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena)
Fedorovich, S. et al. (2017) Reduced synaptic vesicle recycling during hypoxia in cultured cortical neurons (Frontiers in Cellular Neuroscience)
Le Feber, J. et al. (2016): Progression of Neuronal Damage in an In Vitro Model of the Ischemic Penumbra (PLoS One)
Raiss, C.C. et al.(2016): Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology (Scientific Reports)
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Organ-on-Chip Technology Platform: the final workshop
The final workshop in the project hDMT/Nano- Inside: Organ-on-Chip Technology Platform took place at the TU Eindhoven on December 16, 2016. There were twenty participants, who used the workshop to inform each other about the results of the Pilot Projects ... More
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 Erasmus MC hDMT awareness day
The 27th of October 2016 the Erasmus MC hDMT awareness day was organized to introduce hDMT research to the Erasmus MC community and to identify and highlight organs on a chip research lines within the Erasmus MC. Steven Kushner and Marjolein van Driel presented More
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 hDMT consortium meeting
At February 3rd the first annual hDMT Consortium Meeting was held. The meeting was hosted by the Hubrecht Institute in Utrecht. At this "closed" meeting researchers from all hDMT partner organisations who are actively involved in hDMT research, from student to professor, could meet and interact. More
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 Expensive cancer medication
The Dutch Cancer Society (KWF) presented its report 'Zo kan het ook' (in Dutch only), on solutions to keep expensive medication accessible, to Dutch Minister of Health Edith Schippers. hDMT contributed a chapter on Organ-on-Chip technology and cancer care as an innovative business model. Download the report.
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The hDMT newsletter
The hDMT newsletter aims to focus on research, highlights and activities in the Organ-on-Chip field in the context of hDMT. For contributions or suggestions please mail us at info@hdmt.technology
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hDMT documents can be downloaded from the hDMT website
