hDMT newsletter March 2017

In this hDMT Newsletter
Editorial: 2 new partners
IOOCS2017 Symposium 2017 (Lausanne)
hDMT science blog
Upcoming events
Past events
Focus on junior hDMT researchers
Grants and awards
Ongoing research
Recent publications
hDMT activities
hDMT in the news
More about hDMT
Dear reader,
Here we present the first hDMT newsletter in 2017, full of new highlights in the field of organ-on-chip. 

New partners
As of 1 January 2017, hDMT has two new partners. We are pleased to welcome   Welcome at the 2nd International Organ-on-Chip symposium
The École Polytechnique Fédérale de Lausanne (EPFL) and hDMT are happy to invite you for the second International Organ-on-Chip Symposium (IOOCS17). This symposium will be held at EPFL, Lausanne, Switzerland on 2-3 May, 2017. IOOCS17 brings together researchers from different fields to discuss recent developments in organ-on-chip technology and its applications. You will be inspired by international leaders in the field of organ-on-chip technology: 
  • Nancy Albritton, University of North Carolina, Chapel Hill, USA
  • Anne Grapin Botton, University of Copenhagen, Copenhagen, Denmark
  • Kevin Healy, University of California, Berkeley, USA
  • Roger Kamm, MIT, Cambridge, USA
  • Christine Mummery, Leiden University Medical Center, Leiden, The Netherlands
The symposium is a unique opportunity to meet these speakers, and interact with other international scientists in an interactive poster session and a ‘Meet-the-experts’ lunch. The annual series of IOOCS symposia is an initiative of hDMT. After a first successful meeting at University of Twente in The Netherlands in 2016 (IOOCS16), this year’s symposium will be hosted by the Institute of Bioengineering at EPFL.

The organizing committee:
Matthias Lutolf (chair, EPFL)
Albert van den Berg (hDMT)
Christina Mattsson (EPFL)
Christine Mummery (hDMT)
Dietrich Reinhard (EPFL)
Philippe Renaud (EPFL)
Janny van den Eijnden-van Raaij (hDMT)

More information about the symposium and a link to the registration process can be found on the hDMT website. We look forward to your participation and hope you will enjoy the symposium.

For all other hDMT news: please scroll down.
We hope you will enjoy this newsletter.

Christine Mummery, Janny van den Eijnden-van Raaij and Mieke Schutte
Executive board hDMT   
International Organ-on-Chip Symposium 2017

Open for registration!

The 2nd International Organ-on-Chip Symposium 2017 (IOOCS17) will be hosted at the Institute of Bioengineering at EPFL, Lausanne, Switzerland on 2-3 May 2017.In this two-day symposium researchers from different fields are brought together to discuss how chip technology and (stem) cell biology can be combined to ... More  
hDMT science blog

Blog: Coincidence or luck?

Visiting the hDMT technology platform workshop to 'mix-and-match' - A true story (by Yolande Ramos, LUMC).  Almost a year ago, I first heard about hDMT. Immediately I got very enthusiastic: ‘this really is a fantastic initiative’, I thought. Organs-on-Chips had been around for a while already, but by facilitating the union bet... More
Upcoming events
Past events

hDMT at Health-RI Conference

Connecting Researchers, Patients and Enabling Technologies Worldwide, personalized medicine is recognized as the next big dot on the horizon for health care. The Health-RI conference on December 1st 2016 has given an insight into current and future developments of health research infrastructure. Download presentations

Organ-on-Chip at International Micro Nano Conference 2016

13 & 14 December 2016 the International MicroNanoConference took place in the Beurs van Berlage in Amsterdam. We’re looking back at a great event with impressive keynotes and inspiring presentations (download them here). More 

Non-animal approaches; the way forward

Christine Mummery held a presentation on stem cells at a conference organised by the European Union. The conference was intended as a dialogue with the scientific community and stakeholders, on how to exploit the advances in science towards phasing out animal testing. More

MNBS 2016 report

The report on the 10th Annual Concertation and Consultation Workshop on Micro-Nano-Bio-Systems (MNBS 2016) has been published. hDMT participated in the workshop. The report mentions organ-on-chip technology as one of the promising MNBS areas for new discoveries and applications(Download it here).  More
Focus on junior hDMT researchers

A journey towards an extrahepatic islets delivery device with a tissue engineering toolbox in hand (UTwente)

PhD Thesis of Giulia Marchioli on clinical islet transplantation in type I diabetes patients More 

Microgel technology for improved beta cell transplantation (UTwente)

PhD thesis of Sieger Jacob Henke on strategies to encapsulate (beta) cells in micro hydrogels More
Grants and awards

NWO grant for cancer-on-chip

A team led by hDMT researcher Roland Kanaar (Erasmus MC) received an NWO grant in the programme Building Blocks of Life. The team will visualize and quantitate the fundamental process of the DNA damage response, using a microfluidic cancer-on-chip approach. More

NWO grant for gut-on-chip

A team led by hDMT Researcher Hans Bouwmeester (Wageningen University & Research) has received am NWO grant in the programme Building Blocks of Life. The team will unravell the functional dynamics between the human gut microbiome and intestinal inflammatory responses More

Two hDMT projects granted by ZonMw

ZonMw granted two projects by hDMT researchers: Human stem cell-based high-throughput screening platform for cardiac disease (Robert  Passier) and Diseased cardiomyocytes from human stem cells for drug-repurposing and safety pharmacology (Christine Mummery). More

European grant for hDMT researcher

Two projects were granted by ERA-CVD Joint International Call.  Robert Passier (UTwente) and Christine Mummery (LUMC) and Milena Bellin (LUMC) are the hDMT researchers involved. More
Recent Publications

New organ-on-chip publications in hDMT

Gaio, N. et al (2016) Cytostretch, an Organ-on-Chip Platform (Micromachines)

Du, G. et al. (2016) Microfluidics for cell-based high throughput screening platforms – A review (Analytica Chimica Acta)
Ravetto, A. et al. (2016) A membrane-based microfluidic device for mechano-chemical cell manipulation (Biomedical Microdevices)

Van Spreeuwel, A.C.C. et al (2017): Mimicking cardiac fibrosis in a dish: fibroblast density rather than collagen density weakens cardiomyocyte function (Journal of Cardiovascular Translational Research, in press)

Van der Helm, M.W. et al (2016): Direct quantification of transendothelial electrical resistance in organs-on-chips (Biosensors and Bioelectronics)

Kamperman, T et al (2016): Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macrenvironments (Advanced healthcare materials)

Henke, S.J. et al: (2016): Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels (Macromolecular bioscience)

Van Meer, B.J. et al (2016) Small molecule absorption by PDMS in the context of drug response bioassays (Biochemical and Biophysical Research Communications)

Xie S et al. (2016): Displacement Talbot lithography nanopatterned microsieve array for directional neuronal network formation in brain-on-chip Brain-on-chip (Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena)

Fedorovich, S. et al. (2017) Reduced synaptic vesicle recycling during hypoxia in cultured cortical neurons (Frontiers in Cellular Neuroscience)

Le Feber, J. et al. (2016): Progression of Neuronal Damage in an In Vitro Model of the Ischemic Penumbra (PLoS One)

Raiss, C.C. et al.(2016): Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology (Scientific Reports)
hDMT activities

Organ-on-Chip Technology Platform: the final workshop

The final workshop in the project hDMT/Nano- Inside: Organ-on-Chip Technology Platform took place at the TU Eindhoven on December 16, 2016.  There were twenty participants, who used the workshop to inform each other about the results of the Pilot Projects ... More

Erasmus MC hDMT awareness day

The 27th of October 2016 the Erasmus MC hDMT awareness day was organized to introduce hDMT research to the Erasmus MC community and to identify and highlight organs on a chip research lines within the Erasmus MC. Steven Kushner and Marjolein van Driel presented More

hDMT consortium meeting

At February 3rd the first annual hDMT Consortium Meeting was held. The meeting was hosted by the Hubrecht Institute in Utrecht. At this "closed" meeting researchers from all hDMT partner organisations who are actively involved in hDMT research, from student to professor, could meet and interact.  More
hDMT in the news

Expensive cancer medication

The Dutch Cancer Society (KWF) presented its report 'Zo kan het ook' (in Dutch only), on solutions to keep expensive medication accessible, to Dutch Minister of Health Edith Schippers. hDMT contributed a chapter on Organ-on-Chip technology and cancer care as an innovative business model. Download the report.
More about hDMT

hDMT documents can be downloaded from the hDMT website

hDMT flyer 
hDMT white paper
Articles of Association (in Dutch only)
hDMT partner agreement
Procedure for admission and accession of new partners to the hDMT Consortium

Visit  the download page on our website for more documents
For a printed version of the white paper, flyer or FAQ, please contact

The hDMT newsletter

The hDMT newsletter aims to focus on research, highlights and activities in the Organ-on-Chip field  in the context of hDMT. For contributions or suggestions please mail us at

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human Organ and Disease Model Technologies (hDMT)



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