Editorial: Welcome, new hDMT partners!
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 Dear reader,
Here we proudly present the highlights of this 3rd hDMT newsletter.
As of 15 September 2016, hDMT has three new partners. We warmly welcome
Growing Organ-on-Chip network in Europe. hDMT is creating a network of Organ-on-Chip partners in Europe that is essential to place Organ-on-Chip technology on the European research agenda and to include this promising new technology in the new H2020 working programs 2018-2020. The network consists of research groups from Austria (Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology), Germany (TU Berlin; TissUse Berlin; Fraunhofer Institute, Stuttgart; Dept of Exp. Pharmacology and Toxicology, UMC Hamburg), Greece (National Technical University of Athens), Italy (Institute for Microelectronics and Microsystems, Lecce), Portugal (Center for Neurosciences and Cell Biology, Coimbra/ Biocant-Center of Innovation and Biotechnology, Cantanhede) and Switzerland (EPFL, Lausanne) and will be further expanded.
hDMT researchers meet each other in interactive theme meetings. The hDMT theme groups, including Brain-on-Chip, Cancer-on-Chip, Heart-on-Chip, Vessels-on-Chip and the hDMT Technology Platform become up and running.
One year after its official start the hDMT Consortium is now developing into a functional platform where scientists from different disciplines discover the added value of exchanging results and ideas, and collaboration. This has a positive effect on other research groups and companies world-wide and attracts new collaborators in the field of Organ-on-Chip.
We hope you enjoy the news!
For all other hDMT news: please scroll down.
Christine Mummery
Janny van den Eijnden-van Raaij
Mieke Schutte
(Executive board hDMT)
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NEW: hDMT science blog
Our first blogger is Ronald Dekker (TU Delft/Philips). He writes about serendipity, the discovery of something interesting or useful while working on something completely different. He describes a spontaneous and above all fun project between TUDelft, TU/e and Philips Research in which a handful of master students played a leading role More
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- The 3 dimensions of Organ on a Chip, a TNO symposium (31 October 2016, Utrecht, The Netherlands )
- RIVM - KIR-Nano National Platform Nanomedicine: Annual Meeting (3 November 2016, Bilthoven, The Netherlands)
- NRS Symposium Lung Repair and Regeneration (11 November 2016, Schiphol, The Netherlands)
- Health-RI Conference, Empowering Personalized Medicine & Health Research(1 December 2016, Amersfoort, The Netherlands)
- International MicroNanoConference (13-14 December 2016, Amsterdam, The Netherlands)
- ICT.OPEN(21-22 March 2017, The Netherlands)
- Save the date! 2nd hDMT International Organ-on-Chip Symposium (IOOCS2017, 2-3 May 2017, Lausanne, Switzerland)
- Organ-On-A-Chip (a SELECTBIO conference)(10-11 May 2017, Munich, Germany, )
- 10th World Congress on Alternatives and Animal Use in the Life Sciences (20-24 August 2017, Seattle, Washington, USA)
- Microfactories for tissue engineering, or: Regeneration-on-a-chip (26-30 June 2017, Davos, Switzerland)
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 First workshop hDMT/NanoInside technology platform
The first workshop in the hDMT/NanoInside project: 'Organ-on-Chip technology platform' took place at the University of Twente on 15 September. Over 40 researchers and representatives from hDMT partners and hi-tech companies participated in this one-day event that was the official kick-off for this NanoNextNL-sponsored project. More
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 Stakeholders' consultation on cross-KETs for Health: EU current position and future
Janny van den Eijnden-van Raaij (managing director hDMT) represented hDMT and promoted Organ-on-Chip technology during the Stakeholders consultation on cross-cutting key enabling technologies (kets) in Brussels on 14 September 2016. More
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 Opening MERLN Institute
On 8 September the MERLN Institute for Technology-Inspired Regenerative Medicine celebrated its official opening. The institute is part of Maastricht UMC+, one of the new partners of hDMT. More
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 Microengineered 3D analogues of alveolar tissue for lung regeneration
Scientists from four hDMT partners (Erasmus MC, Leiden University Medical Center, Maastricht University Medical Centre+, University of Twente) are developing an Alveolus-on-Chip model for studies on lung repair. The Lung Foundation Netherlands supports this hDMT project with Euro 600 K. The dynamic functional human model will use alveolar epithelial cells and endothelial cells derived from human induced pluripotent stem cells (hiPSC). More
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Development of microfluidic channel embedded in a freestanding PDMS membrane
A team of three PhD students at TU Delft achieved the fabrication of a novel and promising device that consists of a microfluidic channel embedded in a freestanding PDMS membrane. It has the potential to be used as universal Organ-on-Chip platform suitable to model an extensive range of organs. The team succesfully filed a patent regarding the microfluidic device with the legal and financial support of TU Delft. More
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Focus on junior hDMT researchers
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From Fetus towards adult (LUMC)
PhD thesis of Marcelo Catarino Ribeiro on maturation and functional analysis of pluripotent stem cell-derived cardiomyocytes. (From Fetus towards Adult, 13/10/2016, Leiden University/LUMC; Promotors: Christine Mummery, Robert Passier
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Don't skip a beat
PhD thesis of Harsha D. Devalla, on studying cardiac rhythm with human pluripotent stem cell-derived cardiomyocytes (Don't skip a beat, 13/09/2016, University of Leiden, Faculty of Medicine.) Promotors: Christine Mummery, Robert Passier
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 Biond LC files patent and participates in LS@W venture challenge
Nikolas Gaio, Cinzia Silvestri and William Quiros Solano, 3 PhD's at Delft University of Technology, have filed a patent regarding their microfluidic device. Together with 4 other selected startups, their company Biond LC won the opportunity to participate in the Health Holland Life Sciences@Work venture challenge. The winner will be announced at the Dutch Life Sciences Conference in Leiden and will receive 25,000 euros as well as much exposure at this large life sciences business conference. In the past, the Biond LC team received a NanoNext valorisation grant of 100,000 euros. Their device was also considered the most promising business case of the 12StartUp event organized by Yes!Delft.
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 Four joint pilot projects
Four short joint pilot projects have been granted funding (6000 Euro's per project) by the hDMT/NanoInside project 'Organ-on-Chip technology platform'. A fifth proposal has not been granted the pilot status, but will be executed as well. The goal of the technology platform is to promote the interaction between hands-on Organ-on-Chip researchers (students, PhD students or post-docs) from different institutions, as well as the involvement of representatives from relevant private technical partners. More
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The 3 dimensions of organ on-a-chip. TNO White paper 2016 Grootaers G, Ostendorf R,. Bobeldijk I, Hanemaaijer R, Kooter I, van de Sandt H, van de Steeg E, Krul C.
Cytostretch, an Organ-on-Chip Platform Gaio N, van Meer B, Quirós Solano W, Bergers L, van de Stolpe A, Mummery M, Sarro PM Dekker R. Micromachines 2016, 7(7), 120; doi:10.3390/mi7070120
Biology-Inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJAM, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A. t4 Workshop Report) ALTEX 33(3), 2016
A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M. EMBO Mol Med. 2016 Sep 1;8(9):1065-81. doi: 10.15252/emmm.201606260.
Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come? Sala L, Bellin M, Mummery CL. Br J Pharmacol. 2016 Sep 19. doi: 10.1111/bph.13577. [Epub ahead of print] Review.
Regeneration of the lung: Lung stem cells and the development of lung mimicking devices Schilders KA, Eenjes E, van Riet S, Poot AA, Stamatialis D, Truckenmuller R, Hiemstra PS, Rottier RJ. Respir Res. 2016;17(1):44.
TECRL, a novel life-threatening inherited arrhythmia gene associated with a clinical phenotype with overlapping features of both LQTS and CPVT Devalla HD, Gélinas R, Aburawi EH, Beqqali A, Goyette P, Freund C, Chaix MA, Tadros R, Jiang H, Le Béchec A, Monshouwer-Kloots JJ, Zwetsloot T, Kosmidis G, Latour F, Alikashani A, Hoekstra M, Schlaepfer J, Mummery CL, Stevenson B, Kutalik Z, de Vries AAF, Rivard L, Wilde AAM, Talajic N, Verkerk AO, Al-Gazali L, Rioux JD, Bhuiyan ZA Passier R. EMBO Mol. Med. In Press 2016.
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 Report t4 thinktank workshop published
The transatlantic think tank for toxicology (t4) published the report Biology-Inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing. Input came from 36 experts from academia, industry and regulatory bodies during an intensive workshop. Anja van de Stolpe took part as a representative for hDMT. T4 is a collaboration of the toxicologically oriented chairs in Baltimore, Konstanz and Utrecht sponsored by the Doerenkamp Zbinden Foundation. More
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 Wageningen University and Research has joined hDMT
The Department of Agrotechnology and Food Sciences; sections of Toxicology and Microbiology, and Wageningen Research: RIKILT- Institute of Food Safety will from now on be actively participating in hDMT. More
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 TNO has joined hDMT
TNO has an Early Research Program (ERP) Organ-function-on-a-chip, which is a vehicle in which TNO renews and maintains its knowledge base, with an emphasis on intensive collaboration with knowledge partners and stakeholders. TNO recently published a white paper on Organ-on-Chip technology More
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 MUMC+ has joined hDMT
Maastricht University Medical Center + and its MERLN Institute for Technology-Inspired Regenerative Medicine with focus on technologies for regenerative medicine can be seen as flagship in Organ-on-Chip technologies at MUMC+. Organ-on-Chip, Disease-on-Chip and Regeneration-on-Chip are research lines that perfectly fit in MERLNs research strategy for the next decade. More
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 Investment agenda NWA
The Dutch National Research Agenda (NWA) and the Dutch Knowledge Coalition published the Investment Agenda and the Portfolio for research and innovation (both in Dutch). They plead for an extra yearly investment of 1 billion Euro in Dutch research. hDMT is mentioned as an example of a research coalition that should be consolidated and seriously invested in.
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 hDMT and European science policy
Organ-on-Chip technology is becoming popular in European science policy. The effort of hDMT to put Organ-on-Chip technology on the European research agenda and in the new H2020 working programs 2018-2020 is supported by scientific groups in Austria, Germany, Greece, Italy, Portugal and Switzerland. Janny van den Eijnden - van Raaij is representative of hDMT in the RVO-advisory group NMBP (Biotechnology, Nanotechnology, Advanced Materials and Advanced Manufacturing and Processing) for the H2020 working programmes.
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hDMT on Medical Delta website and exhibition
Medical Delta published Humans provide the best model for humans, an interview with Christine Mummery and Janny van den Eijnden - van Raaij. Over the next few months, Medical Delta will be celebrating its tenth anniversary with a travelling exhibition. One of the exhibition panels is about hDMT.
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 Berend van Meer at TEDxYouth@ISH
Organ-on-Chip: the power of combination, was the titel of the talk Berend van Meer (LUMC) presented on October 11th at TEDxYouth@ISH (The Hague International School). The event was organised for a select group of motivated highschool students (14- 17 years old). More
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The hDMT newsletter focuses on research, highlights and activities in the Organ-on-Chip field in the context of hDMT and its partners. For contributions or suggestions please mail us at info@hdmt.technology
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